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Inflammation is a key component and contributor in the pathophysiology of ischemia, existing in every stage of the ischemic cascade (Iadecola and Anrather, 2011)

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Several nanoparticles with enhanced delivery abilities have been developed as well, which includes those attached to the silica core protected by poly(ethylene glycol) chains (PluSNO), CdSe quantum dots, rotaxane-branched radical dendrimers (Gn-TEMPO), G4-polyamidoamine dendrimers, 3Gc0T zero-generation dendrimer, polyurethane dendrimers, gold nanoparticles, liquid crystal nanoparticles, nanosized sterically stabilized liposomes, poly[oligo(ethylene glycol)methyl ether acrylate] and poly(2-hydroxyethyl acrylate) conjugates, and redox nanoparticles