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diuretics or low-dose aspirin (see: The appropriate selection and use of cardiovascular medicines) Dietary factors that increase exposure to purines, such as excessive consumption of red meat, seafood (kaimoana), beer, spirits, sucrose or fructose-sweetened drinks The consequences of poorly-controlled gout are often overlooked Gout can be an intensely painful condition that prevents people from working, performing daily activities and participating in their communities

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[14] Safety interpretation depends on species, exposure route, exposure duration, formulation, impurity profile, study design, and regulatory context

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Abstract Introduction: Sepsis-associated encephalopathy (SAE) is characterized by acute neurological dysfunction and hippocampal damage, with oxidative stress being a key driver of neuronal injury