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Even safety data on TB-500 (synthetic TB4) is relatively scarce, with only a few studies reporting the potential side effects of its systemic application: In a 2010 study in 10 participants, TB4 caused occasional mild to moderate symptoms like headache and dizziness but no serious reactions or toxicities, even at doses up to 1260mg, administered daily for up to two weeks

Nirala Jacobi: No, keep going

Ribose modification Ribose modification is another common strategy that has had notable success

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Collectively, our observations indicate that GCLM KO mice exhibit hepatic and systemic oxidative stress