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Following lyophilized proteins were used: human serum albumin (HSA) from Sigma/Merck (Darmstadt, Germany), alpha-2 macroglobulin (2M) from human plasma (slow form and fast form) and ceruloplasmin (CP) from human plasma were from Athens Research and Technology (Athens, USA), 2M was purchased also from Sigma/Merck (Darmstadt, Germany)

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Recently, several investigators further emphasized the significance of this contribution by showing that the protective and detrimental effects of various proteins in the CP-induced AKI model were mediated via modulation of necroptosis signaling

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