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The results were promising: the triple agonists were more effective at reducing body weight and increasing energy expenditure compared to GLP-1 receptor mono-agonists and GLP-1 receptor/GIP receptor co-agonists

doi: 10.1126/science.abf0529 Summary Keywords ferroptosis pathway, obesity, neurological dysfunction, inflammatory response, metabolic disorders Citation Zhang S, Sun Z, Jiang X, Lu Z, Ding L, Li C, Tian X and Wang Q (2022) Ferroptosis increases obesity: Crosstalk between adipocytes and the neuroimmune system

Furthermore, the introduction of GLP1RAs enabled a reduction or suspension of concomitant insulin therapy in, respectively, 61 and 22% of individuals, thereby decreasing the risk of hypoglycemia and eliminating an additional factor negatively impacting body weight

Protection by pioglitazone in the MPTP model of Parkinsons disease correlates with IB induction and block of NFB and iNOS activation