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The pathophysiology of neuropathic pain varies and includes ectopic activity in damaged nerves or in adjacent nerves, dorsal root ganglion (DRG) or central pathways, and peripheral and central sensitisation involving numerous molecular mechanisms

An increase in GBB has also been shown to attenuate the development of endothelial dysfunction, one of the key factors in high-glucose-induced deep vein thrombosis (DVT) 32

Sections were mounted onto gelatin-coated slides and the slides were coverslipped with Fluoromount G (Electron Microscopic Sciences, Hatfield, PA)

SHMT = serine hydroxymethyltransferase

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