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The microscopy images showed cell rupture and lysis (H&E stain), indicative of signs of cell death (TUNEL stain) in the tumor tissue (Fig

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In addition, increased p53 expression inhibits the expression of the system xc SLC7A11, resulting in reduced uptake of cystine, decreased GSH peroxidase activity, reduced cell antioxidant capacity, and increased sensitivity of cells to ferroptosis (Kang et al., 2019)

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