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Here, the previously determined rAmy-AMY 2 R-Gs was highly dynamic at the extracellular side, transitioning between the consensus (bypass) AMYR conformation and a CT-like conformation (Fig

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Cell Death Dis 6:e1773 LaRocca TJ, Sosunov SA, Shakerley NL, Ten VS, Ratner AJ (2016) Hyperglycemic conditions prime cells for RIP1-dependent necroptosis