The post-meristematic K sensing niche (KSN) plays a key role: a rapid cytoplasmic drop in K, sustained by active transport, produces Ca 2 signals, while the CIFSGN3 LKS4/SGN1 axis activates NADPH oxidases, generates ROS, induces the HAK5 transporter, and accelerates Casparian strip maturation (Zhang et al
Pickart 2015 transcriptomic study reported modulation of multiple thousand genes in fibroblasts at the dose tested
Physiol Rev (1979) 59:527605
Selected references Pickart and colleagues 2018, review on regenerative and protective actions of GHK Cu in the International Journal of Molecular Sciences Pickart 2012, discussion of oxidative stress, inflammation, and mechanistic framing of GHK and copper complexes Simeon and colleagues 2000, dermatology work on wound related effects of the tripeptide copper complex Miller and colleagues 2006, clinical dermatology paper on topical copper tripeptide complex and facial skin endpoints
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