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Mild zinc deficiency can induce quiescence or stall cells in the S phase of the cell cycle by disrupting DNA synthesis and increasing DNA damage 120

Dysregulation will persist to enhance autoreactive T cell activation and lead to disease progression and exacerbation (39)

Patatin-like phospholipase domain-containing 3/adiponutrin deficiency in mice is not associated with fatty liver disease

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Treatment with a histone deacetylase inhibitor, valproic acid, is associated with increased platelet activation in a large animal model of traumatic brain injury and hemorrhagic shock