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Notably, Keap1 inactivation stabilizes Nrf2 and its target genes (such as key components of the SLC7A11/cysteine/glutathione (GSH) axis), promoting resistance to ferroptosis, which is crucial for inhibiting ferroptosis (Cao et al., 2019)

This modification helps the molecule survive digestion and reach cells more effectively, where it can support the body's natural antioxidant defenses

They showed that the less catalytically active PKM2 dimer is upregulated in myofibroblasts with a concomitant increasing NADPH production

You may see these medications referred to as both GLP-1 receptor agonists and GLP-1 inhibitors, which can be confusing