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Melvin et al

It adds that patients who reach goal weight with excellent tolerability and stable metabolic markers may also benefit from continuing, and that a provider should reassess goals, side effect burden, and cost annually

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Their efficacy stems from a multi-targeted mechanism: they ameliorate hepatic steatosis, potently reduce oxidative stress by scavenging ROS and improving redox status, and directly inhibit the activation of the central NF-B inflammatory pathway