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Colesevelam, which requires a much lower quantity of drug because of its high affinity and binding capacity for bile salts, has less of an effect on the absorption of other drugs than other bile acid sequestrants but can still adversely affect the absorption of certain drugs (Table 30) (424)

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In general, since many patients already pay out-of-pocket for GLP-1 drugs, tariff-induced price increases would directly impact affordability and access, potentially limiting the availability of these therapies