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When you do return to exfoliation, we always recommend chemical over physical (so something like an AHA, BHA, glycolic acid, lactic acid, salicylic acid, or retinol not a scrub or scrubbing device) and go gentler than usual the first time, as your skin may be more sensitive than usual

Gradual Effects Some people feel energized immediately, while others notice more gradual improvements in focus, stamina, and mood over the next few days

It ensures that the medication remains uncontaminated until it is ready to be administered

doi: 10.1016/0031-9384(91)90349-s

These patients often require therapeutic doses under medical supervision