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Few studies in animals have indicated that GLP-1 RAs may affect the tone of coronary arteries through inhibition of vasospasm or promotion of vasodilatation ( ex vivo rat models, GLP-1 reversed the contraction of excised coronary artery rings induced by a thromboxane receptor agonist ( The vasodilatory effects of GLP-1 RAs can be mediated through GLP-1 receptors or alternative pathways
2-Deoxy-l-ribose, a stereoisomer of DR, inhibits the promotion of angiogenesis, tumor growth and metastasis by TP (8,9)
Valid considerations include financial accessibility (research peptides cost 60-80% less than retail pharmaceuticals), insurance denial leaving no FDA-approved options, and personal risk tolerance
Limitations and potential biases of the review Although this review provides a comprehensive synthesis of current evidence on GLP-1 RAs as potential gerotherapeutics, several limitations warrant consideration
Weight reduction at least 5% and preferably 10% or more, can be associated with greater histological liver improvements and cardiometabolic benefits
