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Molecular chaperones such as mtHsp60, mtHsp70, and mtDnaJ are the main proteins involved in the UPR mt [51]

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In a methicillin-resistant Staphylococcus aureus (MRSA) infection model, mice treated with spermidine exhibited significantly improved survival rates and enhanced bacterial clearance, providing robust experimental evidence for spermidines potential application in treating infectious diseases and laying the groundwork for its clinical use as an immunomodulator (116)

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