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Conversely, higher levels of FSH lead to azoospermia and severe-oligozoospermia, which are hallmarks for inactive or damaged seminiferous tubules (33)

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Furthermore, recent studies have indicated that p53 may regulate the abnormal differentiation of osteoclasts through the p53/forkhead box protein O3 (FOXO3) signaling pathway, thereby modulating ferroptosis in chondrocytes (Zhao et al., 2025)

Intranasal and intravenous routes have also been studied