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TB-500 is a 43-residue, 4963.4 g/mol thymosin beta 4 sequence acting through G-actin sequestration and integrin-linked kinase signalling, studied mainly in cardiac, corneal, dermal and skeletal muscle models

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Results Enrollment and baseline demographics Herein we report results of a phase 1 clinical trial (www.clinicaltrials.gov, NCT02943239), involving a randomized, double-blind, placebo-controlled comparison assessing the safety, tolerability, pharmacokinetics, and pharmacodynamics of the GDF8 mAb, trevogrumab, and the ActA mAb, garetosmab, each given alone, as well as the GDF8 mAb given in combination with increasing dose levels of the ActA mAb