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GLP-1 helps your body: Increase insulin secretion when glucose is present Improve post meal blood sugar control Slow gastric emptying so you feel fuller longer Signal satiety to the brain GLP-1 receptor agonist medications mimic this hormone

The L-arginine component in particular has been studied pre-meal, with results showing increased postprandial GLP-1 when taken before eating

PMID: 36757157

The glucagon receptor component does introduce metabolic adaptation over time, and varying the stimulus could theoretically disrupt adaptation

NHS guidance also advises everyone to consider 10 micrograms of vitamin D daily during autumn and winter, with year-round supplementation for those with limited sun exposure