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19, the liver and kidneys exhibited higher normalized dosage distribution of Cu 5.4 O USNPs, reaching 7.92 and 7.97 %ID g 1 respectively, while the distributions of NPs in the heart, spleen, lung, and blood reached 2.25, 5.07, 3.02, and 2.84 %ID g 1 , respectively

TABLE 11 In vivo studies using Wistar Rat

Those who had the antibody present in their blood also had an increased severity of disease within the past year and had a far higher scoring for deteriorating joint and bone than those without the antibody