Achieving site-specific transcranial drug delivery to closed-skull TBI patients may be more difficult than the authors imply: the subarachnoid space filled with circulating cerebrospinal fluid (CSF) is about 3-4 mm deep in humans (3), more than an order of magnitude deeper than in mice, permitting CSF to quickly remove drug molecules from a targeted cortical site
3.3 Peptide modulation of autophagy in prostate cancer cells Autophagy constitutes a highly conserved mechanism in evolution that employs lysosomes to degrade cytoplasmic components
Journal of Neurochemistry 109 , 452464, doi:10.1111/j.1471-4159.2009.05966.x (2009)
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They are not a miracle ingredient nothing is but given 12 weeks of consistent use, they deliver visible, measurable structural change