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While the simulations are confined by these assumptions, it is worth noting that redox cycling is governed by thermodynamics, which according to the reduction potential of doxorubicin, are favourable with respect to the formation of superoxide should a semiquinone radical species be present 3

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Parker BA, Sturm K, MacIntosh CG, Feinle C, Horowitz M, Chapman IM (2004) Relation between food intake and visual analogue scale ratings of appetite and other sensations in healthy older and young subjects

Anesthesiology 105:599612