Its metabolically active, less hormonally protected, and more responsive to energy deficits
However, the inaccessibility of hypothalamic-pituitary-gonadal (HPG) tissues in healthy human subjects, and reliance on proxy tissues for epigenome-wide association (EWAS) studies, does not allow this type of study to establish causality or necessarily elucidate the mechanisms responsible for the change in phenotype [5]
Obesity is a chronic disease that requires long-term management, and there is a lack of long-term effective and safe treatments
Regarding the glutamate metabolic pathways, they also found some limited evidence of altered expression of the excitatory amino acid transporter-2 (synaptic re-uptake), glutamine synthetase (glial change of glutamate to glutamine), and glutaminase (presynaptic change from glutamine to glutamate prior to vesicular re-packaging)
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