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Intriguingly, NMR analysis estimated a stronger K D of 1907 for helix 23 (L959 = 1.0 M, K955 = 1.6 M) than for helix 14 (I936 = 27.0 M, K1032 = 25.7 M)

When adverse effects occurred, they were typically mild and transient, with the most common being mild to moderate headaches (similar frequency to placebo groups), minor injection site reactions (redness, slight swelling), and gastrointestinal effects at higher oral doses (nausea, diarrhea)

Nat Med 10(4):382388 Yu J et al (2009) Reticulon 4B (Nogo-B) is necessary for macrophage infiltration and tissue repair

Chemotherapy, immunosuppression, and anesthesia

It is given by subcutaneous injection, sometimes near the area of concern depending on the clinical goal