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Nrf2/HO-1 Signaling Downregulation Promotes Mitochondrial Dysfunction and Neuroinflammation Nrf2/HO-1 has been shown to be a significant pathway involved in suppressing oxidative stress and NLRP3-induced neuroinflammation, but downregulation of this pathway plays a critical role in exacerbating neurodegeneration

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Injectable GHK-Cu Injectable copper peptide protocols (mesotherapy, microneedling with GHK-Cu solution) deliver the peptide directly into the dermis, bypassing the barrier entirely

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