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GLP-1 is classified as an incretin hormone

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GLP-1R knockout mice (GLP-1R KO, Shanghai Model Organisms, based on C57BL/6N) were generated using CRISPR/Cas9 technology, which causes Glp1r gene protein reading frame shift and loss of function by using non-homologous recombination repair to introduce mutations

The FDA continues to explain GLP-1 drugs should not be used in patients with a personal or family history of medullary thyroid carcinoma or multiple endocrine neoplasia syndrome type 2 (MEN 2). Today, experts agree that there is no real risk of thyroid cancer associated with GLP-1 drugs

Nevertheless, to further assess the impact of QMP engineering of the GLP-1 albumin fusion on glycemic control and treatment of T2DM, additional studies are needed in relevant disease models