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A number of published studies have put a fluorescent tag onto GLP-1R agonists, including exendin, liraglutide, and semaglutide, and then used the fluorescent labeling to visualize the distribution of the agonist in the brain (see, e.g., Gabery et al., 2020)

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It was shown through c-Fos immunoreactivity that systemic introduction of Bremelanotide has been shown to activate neurons found in the hypothalamus

10.1172/jci.insight.85717 JCI Insight