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the Oil Red O and BODPIY staining showed that in cholesterol-stimulated INS-1 cells, lipid droplet accumulation was markedly increased compared to that in the control group while it decreased after EX-4 treatment alone or cholesterol co-treatment compared with that in the single cholesterol group (Figure 1I)

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This could be due to the increased demands and utilization of substrate causing a slight increase in ROS production after exercise