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doi: 10.1016/S0140-6736(18)31694-5

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Addressing the Root Causes of Weight Gain : My second theory gets to the heart of my biggest concern with these medications

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We do not prescribe GH-releasing peptides to patients whose IGF-1 is already in the high-normal range for their age, because stimulating further GH elevation in that context produces diminishing returns and increases the theoretical risk of side effects from GH excess