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Aebi S et al
10.1016/j.bbi.2006.08.005 Summary Keywords autism, crocin, curcumin, electron transport chain, quercetin, resveratrol, safranal, vitamins Citation Scenna MS, Bej E, Cesare P, Persichitti I, Cimini A, DAngelo M and Castelli V (2026) Mitochondrial dysfunction and oxidative stress in autism spectrum disorder: pharmacological insights into natural antioxidants
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[20] [7] This conversion is illustrated by the reduction of peroxides (via the sulfenate as an intermediate): GSH + R 2 O 2 GSOR + ROH GSOR + GSH GSSG + ROH Net reaction: 2 GSH + R 2 O 2 GSSG + 2 ROH (R = H, alkyl) and with free radicals, forming glutathionyl radicals (GS ) that may dimerize to disulfide: GSH + R RH + GS 1/2 GSSG Thiyl radicals (such as glutathionyl radicals) are themselves oxidizing species in biology, with a single-electron reduction potential sufficient for oxidation of nucleic acids, proteins and polyunsaturated lipids
