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PMID 25064324

Therefore, in-depth analysis of the exact regulatory network of Bacteroidetes in the pathogenesis of OA through the gut-joint axis, and clarification of the functional specificity of different Bacteroides strains and their interactions with host metabolism, immune and inflammatory pathways, are of great theoretical and clinical significance for accurately understanding the mechanism of the influence of gut microbiota on OA and developing probiotic intervention strategies targeting specific strains

While the mechanism is not yet proven, there is support for the idea that GLP-1 attenuates the ras homolog gene family, member A (RhoA)/Rho-associated protein kinase (ROCK) signaling pathway, whose activation is known to reduce levels of occludin, claudin-5, and zonula occludens-1 (ZO-1), as well as promote disruption of endothelial tight junctions

Animal studies show that it also factors into absorption of vitamins E and K 1

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