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SUMMIT: Tirzepatide Improves Outcomes and Quality of Life For Patients With HFpEF and Obesity In patients with obesity and heart failure with preserved ejection fraction (HFpEF), weekly treatment with tirzepatide over approximately two years reduced the risk of worsening heart failure events, based on findings from the SUMMIT trial presented at AHA 2024 and simultaneously published in NEJM

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Initiation of treatment in patients with NYHA Class III or IV heart failure is CONTRAINDICATED

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This challenge appears across care settings: stigma around injectables and concerns about legitimacy lead some patients to hide use or chase unverified sources, which raises safety issues