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The typical protocol is administering just before bed or early morning, upon an empty stomach

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The Paris Fire Brigade reported that between 1995 and 2003, there was a 41.7% survival rate for 72 patients exposed to cyanide-poisoning through smoke inhalation, and within this group 9 of the the 12 patients with increased systolic blood pressure (bp) treated with hydroxocobalamin demonstrated a recovery of systolic bp to normal (Fortin, 2006)

This neuroprotective effect is thought to result from their ability to absorb glutamate and recycle free radicals