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This suggests that M pro might be particularly efficient at disrupting GSH synthesis, as compared to action at some of the other target sites predicted here, thereby contributing to the clinical findings in COVID-19 ( Finally (Figure 2D), we include a non-canonical hit that would cleave at position 90 of glutaredoxin-1 (GLRX-1)

For example, selenium-containing nanomicelles (PEGPUSePEG/Pt) respond to elevated intracellular GSH by reducing platinum ions from the micelle core, thereby releasing encapsulated doxorubicin (DOX)

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doi: 10.1038/s41598-020-58341-8