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Anthracycline-induced toxicity in this trial did not appear to be worsened by combination with VPA, and other toxicities are manageable providing some reassurance that any synergy in terms of efficacy will not be replicated in unwanted side effects

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The histidine residue serves as the primary copper-binding site through its imidazole ring, creating a stable square-planar copper(II) complex with the amino terminal and adjacent peptide nitrogen atoms