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Monitoring Side Effects Most side effects occur during the dose-escalation phase and are usually temporary

The importance of individualised, holistic treatment in the context of complex clinical decisions was also highlighted by the lack of consensus regarding use of SGLT2is versus GLP-1 RAs in frailty, with differing preferences depending on specific risks or symptoms, requiring clinical judgement to balance efficacy and safety

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Their popularity lies in suppressing appetite and has been further driven by celebs like Oprah Winfrey and Sharon Osbourn, who have openly discussed their use