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Gastric Emptying Modulation Dual Pathway Effect Both components contribute to delayed gastric emptying through complementary mechanisms[5]: GLP3 delays gastric emptying primarily through GLP-1R and glucagon receptor pathways Cagrilintide slows gastric transit through amylin and calcitonin receptor activation Combined effects produce more sustained gastric delay than single agents Prolonged nutrient exposure in the small intestine enhances incretin release This dual-pathway gastric slowing mechanism may explain enhanced satiety and reduced caloric intake observed in combination studies

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doi: 10.1002/ijc.30642 91 ParkYLeitzmannMFSubarAFHollenbeckASchatzkinA

Szabo PA, Dogra P, Gray JI, Wells SB, Connors TJ, Weisberg SP, et al

Do not chew or crush the tablet