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The human microbiome, especially the gut microbiota, comprises numerous symbiotic bacterial species (e.g., Lactobacillus , Bacillus , Clostridium , Enterococcus , and Ruminococcus ) that collectively represent approximately 90% of the gut flora (Rinninella et al., 2019

Similar content being viewed by others Introduction Obesity is a chronic disease characterised by excess adiposity that impairs health and affects about 650 million people worldwide [1, 2]

This is crucial in wound healing, as improved blood flow supports tissue regeneration by delivering oxygen and nutrients to the damaged area

Activation of this pathway is associated with hair growth initiation

Herein it is hypothesized that excessive intake of folic acid depletes serum holotranscobalamin, thereby decreasing active vitamin B-12 in the circulation and limiting its availability for tissues