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However, specific dermatological reactions have been documented in clinical trials and post-marketing surveillance

Many patients begin noticing reduced hunger within the first few weeks, with visible weight changes developing progressively over several months

That understanding shapes everything from study design to endpoint selection to troubleshooting unexpected results

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However, proposed mechanisms include disruption of microtubule function, potential impact on inflammation in the brain, interference with mitochondrial function, contribution to oxidative stress, and possible disruption of the blood-brain barrier