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Dysbiosis, through the lack of appropriate immunoregulatory and barrier factors, such as, e.g., short-chain fatty acids, causes inappropriate activation of the immune system, resulting in epithelial inflammation, epithelial barrier damage and disease development [55, 57,58,59,60,61]

Oral glutathione is inefficiently absorbed, and therapeutic approaches that only use oral supplements tend to struggle with achieving results

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*Correspondence: Junping Zhen, [email protected] Disclaimer All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers