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42 A phase 3 trial including adults with T2DM receiving orforglipron daily (3 mg, 12 mg or 36 mg) showed significant placebo-adjusted reductions in HbA 1c (1.07%) and weight loss (5.9%) at the highest dose

Successful treatment of these underlying gut issues (gut infections, intestinal permeability, microbiome imbalances) with diet, lifestyle, and probiotics can significantly improve these symptoms and even thyroid lab markers [39, 40, 41, 42]