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The final section of this review synthesizes these insights into a forward-looking perspective on the future of peptide therapeutics and articulates why the rediscovery of dormant biology, when guided by modern pharmacologic principles, may represent the most productive frontier in drug discovery
Their mode of action is to mimic the endogenous GLP-1, an intestinal hormone that regulates glucose metabolism and satiety
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Real-world data and observational studies show that individuals who commit to their treatment plan and incorporate balanced nutrition, physical activity, and mindful behaviors tend to maintain substantial weight loss over time
However, tirzepatide works on 2 receptors, GLP-1 and GIP
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