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Major phase I metabolites are 2-OH-ethinyl estradiol and 2-methoxy-ethinyl estradiol

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Ohkuma, T., Iwase, M., Fujii, H

Conversely, the non-significant sites had an average log2 fold-change after 10 min EGF of 0.5, and they mainly belonged to clusters E and F of early negative regulators and late negative regulators with maximum phosphorylation site changes at 20 min of EGF stimulation