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A meta-analysis of 113 RCTs comprising 33,167 patients in the GLP-1 RA cohort and 26,683 in the comparator cohort revealed no significant elevation in pancreatitis or pancreatic cancer risk relative to control groups (Mantel-Haenszel odds ratio [MH-OR] of 0.93 and 0.94, respectively), but identified a notable increase in cholelithiasis risk (MH-OR, 1.30) [58]

How do we know that Mounjaro offers such promise

In classical east asian medicine, they were used for heat pattern type conditions, including what we would nowadays refer to as metabolic syndrome

It is designed around the pharmacokinetics of reaching steady state at each dose before adding more

From what we know from clinical trials, Retatrutide may potentially boost energy while also accelerating calorie burning through the glucagon receptor which has never been seen before in a weight loss treatment