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The warning specifically contraindicates Zepbound in patients with: Personal history of medullary thyroid carcinoma (MTC) Family history of MTC Multiple Endocrine Neoplasia syndrome type 2 (MEN 2) , a hereditary condition that significantly increases MTC risk MEN 2 is an inherited disorder caused by mutations in the RET proto-oncogene, leading to increased susceptibility to MTC, pheochromocytoma, and parathyroid tumors

Comment on Kom et al

GLP-1s often work better for both goals

This pharmacovigilance system is crucial for detecting rare or delayed adverse effects that may not have been apparent in clinical trials

Patients could benefit from multidisciplinary care, with a spectrum of interventions, ranging from early self-directed diet changes to a surgical revision of the primary bariatric surgery