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A physician-supervised plan can help answer whether the medication is appropriate, which option fits the patients risk profile, what dose should be used, how quickly the dose should increase, what side effects should be expected, when the dose should be held or adjusted, how much protein the patient should eat, how muscle can be preserved, what labs should be tracked, and what long-term maintenance should look like

Pieber TR, Bode B, Mertens A, Cho YM, Christiansen E, Hertz CL, et al

This helps ensure you meet your nutrition needs

But it does suggest that the theoretical rationale for combining these compounds is weak even at the mechanistic level

They exist throughout the central nervous system, concentrated in areas that directly regulate mood, emotion, and stress responses