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Silencing SIRT1 gene or inhibiting it pharmacologically with Ex-527 can reduce cell ferroptosis and inhibit EMT, 90 suggesting that epigenetic reprogramming of EMT helps to promote ferroptosis in HNC cells
[PubMed] [Elsevier] Scholz RW, Graham KS, Gumpricht E, Reddy CC
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By contrast, some observational and cross-sectional studies reported no association between sKlotho and AVC, CAC, or AAC in CKD patients, indicating the controversy regarding the role of sKlotho in mediating VC
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