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Selenium and selenoproteins: key regulators of ferroptosis and therapeutic targets in cancer

For example, the catalytic nanosystem composed of erythrocyte membrane (mRBC)-camouflaged hollow MnO 2 (HMnO 2 ) encapsulated lactate oxidase (LOX) and glycolysis inhibitors can deplete lactate in TME and produce oxygen through LOX-catalyzed oxidation of TME, and the combination treatment of tumors with PD-L1 can successfully reverse immunosuppressive in TME by significantly reducing the number of M2 TAMs (24)

Conversely, if a patient presents with pernicious anemia or severe neurological signssuch as intense tingling in the hands, memory loss, or muscle weaknessthe dosage remains the same (usually 1,000 mcg), but the frequency increases significantly

doi: 10.1177/1534735408327251 73 ChobotovaKVernallisABMajidFA

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