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Solar urticaria resembles an allergic reaction

903 In a RANKL-induced osteoclast model, the bisphosphonate zoledronic acid promotes ferroptosis by increasing Fe 2+ , ROS, and MDA levels, and decreasing GPX4 and GSH levels

10.1016/j.ccr.2010.12.014 314 YanagisawaN.IchinoeM.MikamiT.NakadaN.HanaK.KoizumiW.et al

GDH enzymes catalyse the reversible amination of -ketoglutarate to form glutamate (see Figure 1B) with concomitant reduction of NAD(P)H

Of note, Au25Sv9 can effectively inhibit the activation of NF-B induced by RANKL, directly inhibit inflammation-induced differentiation of osteoclasts, and block inflammatory bone destruction (Yuan et al., 2019a)