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The MELK inhibitor OTSSP167 protects intestinal epithelial cells by maintaining a normal composition of gut microbiota and balancing gut microbiota distribution, inhibiting ferroptosis, reducing the expression of pro-inflammatory factors in intestinal tissues, and suppressing the AKT/IKK/P65 and ERK/IKK/P65 signaling cascades in vitro and in vivo, thereby exerting a protective effect on the intestinal tissues of colitis mice [291, 292]

Some users successfully apply their regular facial product (1% to 2%) around the eyes, while others need dedicated eye formulations at reduced strength

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M.Alcocer-GmezE.Castejn-VegaB.Navarro-VillarnE.Conds-HervsM.Mundi-RoldanM.et al (2021)

These lifestyle factors can help reduce oxidative stress and inflammation, which are important factors in lupus management